Gastrointestinal manifestations of children systemic rheumatic disease

Abstract

Children systemic rheumatic diseases are characterized by multisystem involvement,the underlying pathogenesis for gastrointestinal manifestations is deposition of immune complexes in blood vessel walls resulting in ischemia or thrombosis.Gastrointestinal manifestations of these diseases often can't be diagnosed early and correctly,because children can't demonstrate the clinical features accurately,the clinical manifestation varies and often nonspecific,and often confused with the side effect of medicine.Gastrointestinal manifestations are considered rare,comparing with other system involvement,but the consequence can be life-threatening.This makes early and immediate diagnosis and management very important.This paper reviews the various children systemic rheumatic diseases that affect the gastrointestinal tract,including systemic lupus erythematosus,Henoeh Schonlein Purpura,Bechet's disease,mixed connective tissue disease,scleroderma,polyarteritis nodosa,Wegener's granulomatosis,Sjogm's syndrome,dermatomyositis. Key words: Children; Rheumatic disease ; Gastrointestinal manifestation