Abstract

Nervous system has ‘guts’ to produce a variety of gastrointestinal (GI) dysfunction. Among these, focal brain disease causes appetite loss (hypothalamus), decreased peristalsis (presumably the basal ganglia, pontine defecation center/ Barrington's nucleus), decreased abdominal strain (presumably parabrachial nucleus/ Kolliker-Fuse nucleus), hiccup and vomiting (area postrema/ dorsal vagal complex); spinal cord disease causes decreased peristalsis and anismus (tracts, the intermediolateral nucleus) (CNS); and disease affecting the peripheral nerve including the myenteric plexus causes decreased peristalsis with/without loss of bowel sensation (PNS).

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