Abstract
Sleep and the circadian rhythm dynamically influence the physiology of the digestive system. Although studying the gastrointestinal (GI) system during sleep can be challenging, much is to be learned about how this system functions during sleep. The GI system has its own intrinsic rhythms and interacts reciprocally with sleep, and circadian rhythms. New advances in understanding how sleep and these rhythms interact provide an opportunity to evaluate normal physiology and how sleep and circadian disruption influence pathological conditions. Recent work has demonstrated that sleep and circadian factors influence appetite, nutrient absorption, motility, metabolism and the microbiome. Disruption of sleep and circadian rhythms may also increase vulnerability to digestive disorders including reflux, ulcers, bowel inflammation, irritable bowel disease and gastrointestinal cancer. To assess these issues, tools evaluating each of these functions are needed to provide diagnostic and therapeutic opportunities for gastrointestinal disorders.
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