Gastrointestinal Assessment and Therapeutic Intervention for the Management of Exercise-Associated Gastrointestinal Symptoms: A Case Series Translational and Professional Practice Approach.

Stephanie K Gaskell,Ricardo J S Costa,Christopher E Rauch

doi:10.3389/fphys.2021.719142

Stephanie K Gaskell, Ricardo J S Costa + Show 1 more

Open Access

https://doi.org/10.3389/fphys.2021.719142

Copy DOI

Journal: Frontiers in Physiology	Publication Date: Sep 7, 2021
Citations: 27	License type: CC BY 4.0

Affiliation: Monash University

Abstract

This translational research case series describes the implementation of a gastrointestinal assessment protocol during exercise (GastroAxEx) to inform individualised therapeutic intervention of endurance athletes affected by exercise-induced gastrointestinal syndrome (EIGS) and associated gastrointestinal symptoms (GIS). A four-phase approach was applied. Phase 1: Clinical assessment and exploring background history of exercise-associated gastrointestinal symptoms. Phase 2: Individual tailored GastroAxEx laboratory simulation designed to mirror exercise stress, highlighted in phase 1, that promotes EIGS and GIS during exercise. Phase 3: Individually programmed therapeutic intervention, based on the outcomes of Phase 2. Phase 4: Monitoring and readjustment of intervention based on outcomes from field testing under training and race conditions. Nine endurance athletes presenting with EIGS, and two control athletes not presenting with EIGS, completed Phase 2. Two athletes experienced significant thermoregulatory strain (peak core temperature attained > 40°C) during the GastroAxEx. Plasma cortisol increased substantially pre- to post-exercise in n = 6/7 (Δ > 500 nmol/L). Plasma I-FABP concentration increased substantially pre- to post-exercise in n = 2/8 (Δ > 1,000 pg/ml). No substantial change was observed in pre- to post-exercise for systemic endotoxin and inflammatory profiles in all athletes. Breath H2 responses showed that orocecal transit time (OCTT) was delayed in n = 5/9 (90–150 min post-exercise) athletes, with the remaining athletes (n = 4/9) showing no H2 turning point by 180 min post-exercise. Severe GIS during exercise was experienced in n = 5/9 athletes, of which n = 2/9 had to dramatically reduce work output or cease exercise. Based on each athlete’s identified proposed causal factors of EIGS and GIS during exercise (i.e., n = 9/9 neuroendocrine-gastrointestinal pathway of EIGS), an individualised gastrointestinal therapeutic intervention was programmed and advised, adjusted from a standard EIGS prevention and management template that included established strategies with evidence of attenuating EIGS primary causal pathways, exacerbation factors, and GIS during exercise. All participants reported qualitative data on their progress, which included their previously presenting GIS during exercise, such as nausea and vomiting, either being eliminated or diminished resulting in work output improving (i.e., completing competition and/or not slowing down during training or competition as a result of GIS during exercise). These outcomes suggest GIS during exercise in endurance athletes are predominantly related to gastrointestinal functional and feeding tolerance issues, and not necessarily gastrointestinal integrity and/or systemic issues. GastroAxEx allows for informed identification of potential causal pathway(s) and exacerbation factor(s) of EIGS and GIS during exercise at an individual level, providing a valuable informed individualised therapeutic intervention approach.

Highlights

Exercise-associated gastrointestinal symptoms are a common feature of endurance exercise, and can vary in severity from a minor level of discomfort and inconvenience to severe symptoms of clinical significance
It is well established that the underlying pathophysiology of gastrointestinal symptoms (GIS) during exercise is multifaceted, and appears to stem from “exercise-induced gastrointestinal syndrome” (EIGS), involving two primary causal pathway models, and a potential third causal factor in form of mechanical strain
The neuroendocrine-gastrointestinal pathway of EIGS appears to be the predominant causal pathway of acute GIS during exercise, compared with the circulatory-gastrointestinal pathway, which does not appear to play a consistent key role in evoking GIS during exercise (Costa et al, 2017a; Snipe et al, 2018a,b; Gaskell et al, 2021b). This pathway has been implicated in promoting gastroparesis with or without paralytic ileus during exercise, which appears to promote acute onset of severe GIS during exercise (Costa et al, 2019; Gaskell et al, 2021b)

Summary

Introduction

Exercise-associated gastrointestinal symptoms are a common feature of endurance exercise, and can vary in severity from a minor level of discomfort and inconvenience to severe symptoms of clinical significance. The neuroendocrine-gastrointestinal pathway of EIGS appears to be the predominant causal pathway of acute GIS during exercise, compared with the circulatory-gastrointestinal pathway, which does not appear to play a consistent key role in evoking GIS during exercise (Costa et al, 2017a; Snipe et al, 2018a,b; Gaskell et al, 2021b). This pathway has been implicated in promoting gastroparesis with or without paralytic ileus during exercise, which appears to promote acute onset of severe GIS during exercise (Costa et al, 2019; Gaskell et al, 2021b). Ultra-endurance athletes (i.e., runners and/or cyclists) commonly complain of rapid onset of GIS during exercise ∼4 h into exercise, in which, there is accruing laboratory research presenting disturbance to gastrointestinal function (e.g., motility, digestion and/or absorption) and feeding intolerance being the main instigators of this later onset GIS during exercise (Costa et al, 2017a, 2019; Alcock et al, 2018; Miall et al, 2018; Gaskell et al, 2020, 2021b; Russo et al, 2021a,b,c)

Methods

Results

Discussion

Conclusion