Gastroesophageal flap valve reflected EGJ morphology and correlated to acid reflux

Chenxi Xie,Yinglian Xiao,Ning Zhang,Minhu Chen,Yuwen Li,Lishou Xiong

doi:10.1186/s12876-017-0693-7

Abstract

ObjectiveThe anatomy of esophagogastric junction (EGJ) serves as the anti-reflux barrier. The gastroesophageal flap valve (GEFV) is a component of EGJ. The aim of the current study was to assess its correlation with the esophageal acid exposure and the impact on anti-reflux barrier function by using the metrics of EGJ contraction.MethodsEighty three patients with typical GERD symptoms were included in the study. Upper endoscopy, high-resolution manometry (HRM) and 24 h multichannel intraluminal impedance-pH (MII-pH) monitoring were performed in all patients. GEFV was determined as four grades during endoscopic examination based on the Hill classification. The esophageal pressure topography (EPT) metrics defined in the updated Chicago Classification were measured by HRM, including integrated relaxation pressure (IRP), EGJ contractile index (EGJ-CI),expiratory EGJ pressure(EGJP-exp) and inspiratory EGJ pressure (EGJP-insp).ResultsThe GEFV grade III and IV was more commonly found in patients with esophagitits (p < 0.05). The acid exposure time (AET%) and supine AET% were lower in patients with GEFV grade I (p < 0.01). There was weak correlation between AET% and GEFV grades (r = 0.27, p = 0.013). There were more EGJ morphology type III in patients with GEFV grade IV (p < 0.05).There were no significant differences on the values of four HRM metrics among the patients with different GEFV grades (p > 0.05).ConclusionThe GEFV grades were associated with acid reflux positively and could be a good reflection of EGJ morphology in HRM. But it had no impact on the four HRM metrics. Our research revealed that GEFV may play an assistant role in the anti-reflux barrier.

Highlights

The dysfunction of anti-reflux barrier was a main cause for gastroesophageal reflux disease (GERD)
Demographic characteristics of the patients Thirty-three patients with erosive esophagitis (7 patients with LA-A grade, 24 patients with LA-B grade, 2 patients with LA-D grade), 34 patients with nonerosive reflux disease (NERD) and 16 patients with reflux hypersensitivity were included in the study (Table 1)
51.5% patients with gastroesophageal flap valve (GEFV) III/IV were included in the erosive esophagitis (EE) group, 26.5% in the NERD group and 18.8% in the group with reflux hypersensitivity (p = 0.032, Table 2)

Summary

Introduction

The dysfunction of anti-reflux barrier was a main cause for gastroesophageal reflux disease (GERD). The esophagogastric junction (EGJ) plays the fundamental role for the barrier. The anatomical structures of EGJ are complex, containing lower esophageal sphincter (LES), crural diaphragm (CD), His angle and flap valve. The gastroesophageal flap valve (GEFV) is a 180-degree musculomucosal fold apposite to the lesser curvature of stomach as viewed with a retroflexed endoscope [1]. It is created by the intraluminal extension of His angle. The GEFV was first described by Thor et al in 1987 [2], and the grading system was created by Hill et al in 1996 [1].

Methods

Results

Discussion

Conclusion