Gastroduodenal Ulcers and ABO Blood Group: the Japan Nurses’ Health Study (JNHS)

Lobna Alkebsi,Junko Nakajima-Shimada,Hiroshi Ohnishi,Jung-Su Lee,Yuki Ideno,Kunihiko Hayashi,Yasunori Sato,Shosuke Suzuki

doi:10.2188/jea.je20160204

Lobna Alkebsi, Junko Nakajima-Shimada + Show 6 more

Open Access

https://doi.org/10.2188/jea.je20160204

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Abstract

BackgroundAlthough several studies have shown that blood type O is associated with increased risk of peptic ulcer, few studies have investigated these associations in Japan. We sought to investigate the association between the ABO blood group and risk of gastroduodenal ulcers (GDU) using combined analysis of both retrospective and prospective data from a large cohort study of Japanese women, the Japan Nurses’ Health Study (JNHS; n = 15,019).MethodsThe impact of the ABO blood group on GDU risk was examined using Cox regression analysis to estimate hazard ratios (HRs) and 95% confidence intervals (CI), with adjustment for potential confounders.ResultsCompared with women with non-O blood types (A, B, and AB), women with blood type O had a significantly increased risk of GDU from birth (multivariable-adjusted HR 1.18; 95% CI, 1.04–1.34). Moreover, the highest cumulative incidence of GDU was observed in women born pre-1956 with blood type O. In a subgroup analysis stratified by birth year (pre-1956 or post-1955), the multivariable-adjusted HR of women with blood type O was 1.22 (95% CI, 1.00–1.49) and 1.15 (95% CI, 0.98–1.35) in the pre-1956 and post-1955 groups, respectively.ConclusionIn this large, combined, ambispective cohort study of Japanese women, older women with blood type O had a higher risk of developing GDU than those with other blood types.

Highlights

The ABO gene on chromosome 9q34 encodes glycosyltransferases that catalyze the transfer of nucleotide donor sugars to the H antigen to form the ABO blood group antigens.[1]
The association between ABO and peptic ulcer was one of the first to be identified,[6] and it was shown that individuals with blood type O had a higher susceptibility to peptic and duodenal ulcers compared with individuals with other blood types.[7]
The 13,449 participants responded to the 2-year questionnaire, including questions of ABO blood type and Rh factor type

Summary

Introduction

The ABO gene on chromosome 9q34 encodes glycosyltransferases that catalyze the transfer of nucleotide donor sugars to the H antigen to form the ABO blood group antigens.[1]. We conducted an ambispective analysis of the ABO blood group and risk of gastroduodenal ulcers (GDU) in the Japan. Several studies have shown that blood type O is associated with increased risk of peptic ulcer, few studies have investigated these associations in Japan. We sought to investigate the association between the ABO blood group and risk of gastroduodenal ulcers (GDU) using combined analysis of both retrospective and prospective data from a large cohort study of Japanese women, the Japan Nurses’ Health Study (JNHS; n = 15,019)

Methods

Results

Conclusion