Abstract
Nowadays, there is no agreed about the definition of gastritis, the most used definition is the one that describes gastritis like microscopic inflammation of gastric mucosa. There is no relationship between the presence of gastritis and the appearance of gastric symptoms or endoscopic lesions. The most frequent causes of gastritis are the gastric infection with Helicobacter pylori and the antiinflammatory use. Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most widely prescribed medication in the world. Their main benefit derives from their anti-inflammatory and analgesic effect, but the use of these agents is not innocuous since they mainly increase the risk of gastrointestinal (GI) and cardiovascular complications compared with non-NSAID users. NSAIDs users at-risk should be considered for alternatives to NSAID therapy and modifications of risk factors. If NSAID therapy is required, patients at risk will need prevention strategies including cotherapy of NSAID with gastroprotectants (PPI or misoprostol) or the prescription of COX-2 selective inhibitors.
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