Gastrin Inhibition of Intestinal Absorption in Dogs

Abstract

We compared the effects of endogenous gastrin and exogenous pentapeptide on intestinal absorption of sodium, potassium, water, and glucose. Jejunal and ileal loops were isolated from the rest of the gut in anesthetized dogs, and a physiological solution containing these substances was instilled in the loops for 15-min periods. Absorption was determined by the recovery of water and solutes in the solution evacuated from the loops. Intravenous pentagastrin (5.0 μg per kg-hr) inhibited absorption of sodium, potassium, and water from the ileum and jejunum and glucose from the ileum. Endogenously released gastrin (evoked by instilling a 5% acetylcholine solution in the stomach to bathe the antral mucosa) caused inhibition of absorption of sodium, potassium, water, and glucose from both jejunal and ileal loops. Intravenously administered secretin had no effect on intestinal absorption in this preparation.