Abstract
The influence of gastrin on calcium homeostasis was studied in both thyroid intact and thyroparathyroidectomized (TPTX) rats. Either synthetic human gastrin I or porcine gastrin was injected intravenously into fasted, anesthetized male rats. Venous blood was collected before gastrin administration and both at 30 and 60 min after injection. Gastrin doses of 12–50 μg/rat induced a significant hypocalcemic response in thyroid intact rats. Similarly, gastrin doses of both 12 and 25 μg/rat also produced a significant decrease in serum calcium in TPTX rats. These studies strongly suggest that gastrin-induced hypocalcemia in the rat is not solely dependent upon the thyroid release and subsequent action of calcitonin.
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