Abstract
The presence of gastrin/cholecystokinin (CCK)-like immunoreactive material in neurones of the brain of the blowfly, Calliphora erythrocephala, has been demonstrated by means of the peroxidase-antiperoxidase immunocytochemical technique. Results from a range of antisera directed against different parts of either the gastrin or the CCK molecule suggest that the Calliphora material is COOH-terminal specific. The immunoreactive neurones occur in well-defined regions of the brain and include certain cells within the median neurosecretory cell groups of the pars intercerebralis. The phylogenetic implication is that the gastrin/CCK peptide series was established early in evolution within neuronal elements of invertebrates.
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