Abstract
The objective of the current investigation is to formulate ethyl cellulose and hydroxypropyle methyle cellulose based sustained release microspheres, containing lansoprazole as model drugs. lansoprazole is type II anti-ulcer agent when administered shows synergetic effect in their action. Microspheres were prepared by W/O/O double emulsion solvent evaporation method with different stabilizer concentration and at different speeds of emulsification while maintaining constant amount of lansoprazole. Drug excipient compatibility study was performed prior to formulation development and only compatible excipients were used in the fabrication of microspheres. Prepared microsphere formulations were characterized by percentage yield, particle size analysis, entrapment efficiency, invitro release behavior, differential scanning colorimetry (DSC) and scanning electron microscopy (SEM). SEM studies showed that the microspheres were spherical with rough surface morphology. The drug loaded microspheres showed 10.4-57.9% entrapment capacity for lansoprazole and The invitro release profile showed a slow and steady release pattern for lansoprazole. A 95-98% was releases within a period of 12 hrs . The drug release was found to be diffusion controlled mechanism. The n value of Korsmeyer Peppas equation indicated non Fickian type of diffusion.
Highlights
Sustained Release FormulationFor decades an acute or chronic illness is being clinically treated through delivery of drugs to the patients in form of some pharmaceutical dosage forms like tablets, capsules, liquids, creams, pills, aerosols, injectable, and suppositories with their main discrepancy to maintain drug levels within the therapeutic range
It should be emphasized that the plasma level of a drug should be maintained within the safe margin and effective range.For this, proper and calculated doses of the drug need to be given at different time interval by conventional dosage form
To achieve as well as to maintain the concentration within the therapeutically effective range needed by the treatment by repeated administration a day, results in a significant fluctuation in a plasma drug level, leads to several undesirable toxic effects, and poor patient compliance.2The loopholes of the conventional dosage forms lie in their inability: Controlled drug delivery systems have been introduced to overwhelm the drawback of fluctuating drug levels associated with conventional dosage forms
Summary
Sustained Release FormulationFor decades an acute or chronic illness is being clinically treated through delivery of drugs to the patients in form of some pharmaceutical dosage forms like tablets, capsules, liquids, creams, pills, aerosols, injectable, and suppositories with their main discrepancy to maintain drug levels within the therapeutic range. When conventional immediate release dosage forms are taken on schedule and more than once daily, there are sequential therapeutically blood peaks and valley associated with taking each dose. To achieve as well as to maintain the concentration within the therapeutically effective range needed by the treatment by repeated administration a day, results in a significant fluctuation in a plasma drug level, leads to several undesirable toxic effects, and poor patient compliance.2The loopholes of the conventional dosage forms lie in their inability: Controlled drug delivery systems have been introduced to overwhelm the drawback of fluctuating drug levels associated with conventional dosage forms.
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