Abstract
BackgroundAdjuvant radiotherapy following surgery reduces the local recurrence and improves the prognosis. However, a considerable part of patients developed digestive reaction in daily treatment. In order to explore the correlation between breast radiotherapy and gastric toxicity, we investigated the clinic symptoms and stomach dose during DIBH or FB mode while left-sided breast cancer patients (LSBCP) receiving radiotherapy.MethodsIn the study, 124 LSBCP received adjuvant radiotherapy after surgery at our department were analyzed clinical characteristics and enquired about gastrointestinal side effects after treatment. Moreover, dosimetric parameters were assessed.ResultsThere was no statistically significant difference between the two groups in age, T staging, N staging, hormone receptors, human epidermal receptor-2 (HER2), surgical methods, fractionated regimen, and chemotherapy conditions. However, larger stomach volumes and higher fractionated dose (Dmax/F) were associated with a statistically significantly greater risk for acute radiotherapy toxicity. In addition, the use of the DIBH gating technique (FB/DIBH) reduced the incidence of digestive reactions.ConclusionIn order to cut down gastric side effects after breast radiotherapy, large meals should be avoided before treatment. DIBH treatment should be implemented in centers where conditions are satisfied to reduce radiotherapy side effects. Furthermore, dose limitation in stomach should be considered when the radiotherapy plan was formulated, especially for the patients treated with hypofractionated radiotherapy.
Highlights
Breast cancer is one of the most common cancers diagnosed in women [1]
Digestive reaction might result in weight loss, even further cause changes in body shape, which should be rigorously avoided during radiotherapy
As gastric side effects have not been widely attracted attention to, the main objective of this study is to prove the existence of gastric side effects in the process of breast cancer radiotherapy
Summary
Breast cancer treatment is based on comprehensive therapy, consists of surgery, Yang et al Radiation Oncology (2022) 17:2 cancer patients suffered radiation-induced nausea and vomiting (RINV) during radiotherapy [13]. It’s essential for radiation therapists to recognize the digestive symptoms during radiotherapy in left-sided breast cancer patients (LSBCP). Possible related primary factors responsible for the detrimental effects might be found by analyzing the patients’ characteristics. Radiation therapists can keep the side effects occurrence as low as possible. A considerable part of patients developed digestive reaction in daily treatment. In order to explore the correlation between breast radiotherapy and gastric toxicity, we investigated the clinic symptoms and stomach dose during DIBH or FB mode while left-sided breast cancer patients (LSBCP) receiving radiotherapy
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