Abstract
Summary The effects of acute isotonic extracellular fluid volume expansion were studied in conditioned, anesthetized dogs who underwent pyloric ligation and creation of an external gastric fistula. A hypervolemic state was produced with intravenous Ringer's lactate solution. The canine stomach responded as a “third-kidney” by significantly increasing gastric juice volume (528 per cent) and gastric acid output (696 per cent). This occurred paradoxically in the presence of a lactate load and a metabolic alkalosis.
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