Abstract
The effect of intracerebral stimulation on the basal gastric secretory response was examined in unanesthetized, unrestrained cats equipped with a permanent gastric fistula and indwelling electrodes. Stimulation of the corpus callosum-cingulate gyrus area produced a significant increase in total acid output without concomitant behavioral and somatomotor changes. One of these responses was accompanied by an increase in pepsin output while the other showed a concurrent decrease in secretory volume and chloride output. Stimulation of the sites located in the ventral anterior and lateral posterior thalamic nuclei, cerebral peduncle-substantia nigra region, and reticular mesencephalic substance failed to elicit a significant gastric secretory response even at intensities which produced gross autonomic, behavioral and somatomotor changes. The results suggest that the corpus callosum-cingulate gyrus region plays an important role in regulating gastric secretory function. The responses appeared to be entirely neural in nature and compared favorably with those previously observed following amygdaloid and supraoptic stimulation.
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