Abstract
An association has been reported between chronic renal failure and peptic ulcer. In this study, gastric acid secretion was measured in 106 patients undergoing treatment for chronic renal failure and in 24 normal subjects. Compared with controls, 32 undialysed uraemic patients had no significant difference in basal or peak acid output, although 7 of the 32 (22%) showed hyposecretion. In contrast, 36 patients undergoing regular dialysis had significant elevations of basal and peak acid output. In 38 renal transplant patients, basal and peak acid outputs were also significantly elevated, but peak acid output tended to fall with time after transplantation.
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