Abstract
Experimental polycythemia was induced in rats by repeated intravenous transfusion of homologous packed erythrocytes. Rats were bearing permanent gastric cannulas and some of them had bilateral truncal vagotomy. When polycythemia was established, 24-hour gastric secretion studies were performed. During the collection of gastric juice, rats received continuous intravenous infusion of histamine or of the anticholinergic drug propantheline bromide (Pro-Banthine). Control animals were infused by normal saline. At the end of the experiment gastric mucosa of polycythemic and control rats was studied macro- and microscopically. In all polycythemic rats in which HCl and pepsin were found in gastric secretion, severe peptic ulcers of glandular mucosa were found. Vagotomized polycythemic animals in which HCl secretion was abolished had no peptic ulcers. Severity and number of ulcers were not directly related to the amount of HCl and pepsin secreted in 24 h. The etiology of these ulcers remains unexplained.
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