Abstract
Purpose: Acid in the gastric refluxate is a key contributor to mucosal injury in GERD. Hence, quantification of gastric acid secretion is a logical measure of efficacy of medical therapy for GERD. Gastric acid output (GAO = [H+] gastric volume) measures actual gastric acid secretion. However, intragastric pH is frequently used to assess the efficacy of proton pump inhibitor therapy. The purpose of this study was to assess the accuracy of intragastric pH as a measure of gastric acid secretion and potential esophageal acid load.
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