Abstract
Objective. Satiation has recently been shown to be associated with gastric volume or gastric tone. Electrical stimulation has been shown to reduce food intake and increase gastric volume, or reduce gastric tone. The aim of this study was to investigate the correlation between gastric or intestinal electrical stimulation (GES/IES)-induced increase in gastric volume and food intake. Material and methods. GES/IES was performed on 14 dogs implanted with electrodes and a gastric cannula. Food intake was measured and gastric volume was assessed using barostat with or without GES/IES. Results. Food intake was correlated to weight (r=0.62, p = 0.02) as well as the fasting gastric volume (r=0.59, p=0.02). GES/IES reduced food intake (240.8 versus 445.0 g, p<0.005) and increased gastric volume in the fasting state (263.4 versus 74.4 ml, p<0.0001). Reduced food intake was correlated to the preprandial gastric volume (r= − 0.58, p=0.02) and postprandial increase in gastric volume with GES/IES (r=0.56, p=0.03). Conclusions. GES/IES reduces food intake and increases gastric volume measured by barostat. The GES/IES-induced increase in gastric volume (or reduced gastric tone) is correlated with reduced food intake during GES/IES.
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