Abstract
There are few English reports on secondary tumors from heterotopic pancreas. Here, we describe a case of gastric neuroendocrine tumor (NET) arising from heterotopic pancreas. A 72-year-old woman underwent esophagogastroduodenoscopy as part of a general health check-up. An endoscopic examination revealed a submucosal tumor on the greater curvature of the gastric body. Laparoscopic and endoscopic cooperative surgery was performed. Histological diagnosis concluded that it was a Grade 1 NET arising from heterotopic pancreas. We report this extremely rare case of a NET presenting as a submucosal tumor, considered to have originated from heterotopic pancreatic tissue.
Highlights
Neuroendocrine neoplasms of the stomach are relatively uncommon
The usual location of heterotopic pancreas is the stomach in 25–38% of cases, the duodenum in 17–35% of cases, and the jejunum in 15–21.7% of cases
Many gastric neuroendocrine tumor (NET) arise in the body or fundic mucosa; 1 3
Summary
Most neuroendocrine neoplasms are neuroendocrine tumors (NETs) that are well-differentiated, nonfunctioning enterochromaffin-like cell tumors arising predominantly in the corpus–fundus region. They encompass three distinct types—type I tumors are associated with autoimmune gastritis, type II tumors are associated with multiple. Heterotopic pancreas is commonly situated in the submucosa of the distal stomach, most often within 5 cm of the pylorus. It is seen during endoscopy as a solitary, umbilicated submucosal lesion with occasional erosion of the overlying mucosa. We report an extremely rare case of a NET presenting as a submucosal tumor, considered to have originated from ectopic pancreatic tissue.
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