Abstract
Many patients with gastroesophageal reflux disease (GERD) may also have overlapping symptoms of dyspepsia. The aim of this study was to investigate gastric myoelectrical characteristics and gastric response to a water load in GERD patients with or without dysmotility-like dyspepsia. The study included 20 GERD patients with dysmotility-like dyspepsia (GERD+) and 17 patients with GERD only. Electrogastrogram (EGG) was assessed using cutaneous electrodes before and after a subject ingested water until full. GERD+ patients ingested smaller volumes of water compared to patients with GERD (p＜0.05). At baseline, the percentage of gastric myoelectrical power in the normal 3 cpm (cycles per minute) range was significantly less in patients with GERD+ compared with GERD subjects (p=0.001). Power in the 1-2.5 cpm bradygastria range was signficant1y greater in patients with GERD+ (p=0.005). The GERD+ group had a significant increase of the percentage of power in the 3.75-10.0 cpm tachygastria range later after the water load (p＜0.01). In conclusion, gastric myoelectrical abnormality is detected through EGG in GERD patients with dysmotility-like dyspepsia and these patients might have altered perception of stomach fullness.
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