Abstract
Gastrointestinal anaphylaxis alters the integrity of the intestinal mucosal barrier in various ways. IgE mediated anaphylaxis increases intestinal permeability, may lead to mucosal damage and may trigger the release of intestinal globlet cell mucus.(1) Furthermore, there is enhancement of dietary antigen uptake in the intestine during anaphylactic reactions.(2) Such enhanced uptake of dietary antigens may stimulate the production of antibodies to these antigens. Macromolecular antigen uptake has only been considered to take place in the small intestine. We have developed a murine model to test the effect of systemic and local anaphylaxis on the gastric mucosal barrier and on the uptake of a bystander antigen from the stomach into the systemic circulation.
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