Abstract
Gastric lipase is one of the prepancreatic lipases found in some mammalian species and in humans. Our knowledge of the hormonal regulation of gastric lipase secretion in children and adolescents is still very limited. The aim of this study was to compare the activity of human gastric lipase (HGL) in gastric juice in healthy adolescents and in patients with gastritis. The adolescents were allocated to three groups: the first including patients with Helicobacter pylori gastritis (HPG; n = 10), the second including patients with superficial gastritis caused by pathogens other than H. pylori (non-HPG; n = 14) and the control group including healthy adolescents (n = 14). Activity of HGL was measured in gastric juice collected during endoscopy. Plasma concentrations of cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) were measured in all adolescents. Activity of HGL in the non-HPG group was significantly lower than in the HPG group (p < 0.005) and the control group (p < 0.005). Mean plasma GIP levels in the control group were lower than in the non-HPG group (p < 0.003) and the HPG group (p < 0.01). We conclude that the regulation of HGL secretion by GLP-1 and CCK is altered in patients with gastritis. Moreover, GIP is a potent controller of HGL activity, both in healthy subjects and in patients with gastritis.
Highlights
Gastric lipase is one of the mammalian preduodenal lipases [1,2,3].Immunochemical studies revealed that human gastric lipase (HGL) is secreted by the chief cells of gastric mucosa [4]
The aim of our study was to evaluate the activity of HGL in gastric juice collected from adolescents with superficial gastritis caused by Helicobacter pylori and with superficial gastritis caused by other factors, as well as from healthy subjects
We found no differences of acidity of the gastric juice between the study groups
Summary
Gastric lipase is one of the mammalian preduodenal lipases ( termed prepancreatic lipases) [1,2,3].Immunochemical studies revealed that human gastric lipase (HGL) is secreted by the chief (zymogen) cells of gastric mucosa [4]. HGL takes part in digestion of fats, and it accounts for approximately 40% of preduodenal lipolysis. The activity of pancreatic lipase is low, and the bile salt stimulated lipase (BSSL), present in breast milk, and HGL are important for digestion of fats in this period of life [5]. It has been suggested that in healthy subjects, the regulatory peptides, like glucagon-like peptide-1 (GLP-1) and cholecystokinin (CCK), may influence secretion and/or activity of HGL [12]. Another peptide taking part in the regulation of the upper gastrointestinal function is glucose-dependent insulinotropic peptide (GIP), but we have not identified any data on the effects of GIP on gastric lipase secretion. Little is known about the regulation of HGL secretion in patients with gastric disorders, including gastritis, which is the most common gastric condition
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