Abstract
Neoplasms of the digestive system are uncommon in dogs, and may be of epithelial, neuroendocrine, hematopoietic and mesenchymal origin. The leiomyosarcoma is a tumor of mesenchymal origin of smooth, malignant, slow-growing muscles. Paraneoplastic syndromes can affect different systems, being the most commonly found: hypercalcemia, hypoglycemia, cachexia and anemia. There are rare cases of mesenchymal tumors of the gastrointestinal tract in dogs that result in hypoglycaemia with clinical signs. The objective of this study is to report a case of gastric leiomyosarcoma associated with clinical hypoglycemia. The patient had neurological signs such as ataxia and seizures associated with hypoglycemia, which did not recur after surgical excision of the tumor. The definitive diagnosis was based on the histopathological and immunohistochemical examination of the tumor.
Highlights
Gastric neoplasms, such as leiomyosarcoma, are uncommon in dogs [1] [2] [3] and occur in less than 1% of all tumors of the species [3] [4]
The objective of this study is to report a case of gastric leiomyosarcoma associated with clinical hypoglycemia
The patient had neurological signs such as ataxia and seizures associated with hypoglycemia, which did not recur after surgical excision of the tumor
Summary
Gastric neoplasms, such as leiomyosarcoma, are uncommon in dogs [1] [2] [3] and occur in less than 1% of all tumors of the species [3] [4]. Hypoglycemia (serum glucose lower than 65 mg/dL), associated with oncology patients, has as its main cause insulinoma. It may occur as a consequence of a paraneoplastic syndrome and has been described in hepatocellular carcinoma, lymphoma, hemangiosarcoma, oral cavity melanoma, hepatoma, gastric leiomyosarcoma and multiple myeloma [9] [10] [11]. The clinical signs commonly related to hypoglycemia are seizures, disorientation, paresis, weakness, tachycardia, among others. These neurological signs are observed when glycemia is less than 45 mg/dL [11] [12] [13]. The objective of this study is to report a case of hypoglycemia associated with gastric tumor in a dog
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