Abstract
BackgroundEmerging reports demonstrated that PIWI‐interacting RNAs (piRNAs) played an indispensable role in tumorigenesis. However, it still remains elusive whether piR‐1245 in gastric juice specific in stomach could be employed as a biomarker for gastric cancer (GC). The present work is aiming at exploring the possibility of piR‐1245 in gastric juice as a potential marker to judge for diagnosis and prognosis of gastric cancer.MethodsGastric juice was collected from 66 GC patients and 66 healthy individuals. Quantitative real‐time reverse transcriptase polymerase chain reaction (qRT‐PCR) was employed to measure the levels of piR‐1245 expression. Then, the pattern of piR‐1245 expression in gastric juice was determined between GC patients and healthy individuals. A receiver operating characteristic (ROC) curve was constructed for distinguishing GC from healthy individuals.ResultsGastric juice piR‐1245 levels in GC were higher than those of controls (P < .0001). The value of area under ROC (AUC) was 0.885 (sensitivity, 90.9%; specificity, 74.2%; 95% confidence interval, 0.8286 to 0.9414). High gastric juice piR‐1245 expression was signally correlated with tumor size (P = .013) and TNM stage (P = .001). GC patients with high piR‐1245 expression in gastric juice exerted a poorer overall survival (OS) (P = .0152) and progression‐free survival (PFS) (P = .013). COX regression analysis verified that gastric juice piR‐1245 expression was an independent prognostic risk variable for OS (P < .05).ConclusionsThe current study suggested that piR‐1245 in gastric juice had the potential to be a useful biomarker for GC detection and prognosis prediction.
Highlights
Gastric cancer (GC) is a frequent malignancy all over the world, and its incidence has been increasing over the past decade.[1]
We firstly explored the expression pattern of piR-1245 in gastric juice (GJ); we uncovered its clinical value in the GJ as an additional indicator for gastric cancer (GC)
If carcinoembryonic antigen (CEA) was used as the diagnostic marker of GC, area under ROC (AUC) was 0.642
Summary
Gastric cancer (GC) is a frequent malignancy all over the world, and its incidence has been increasing over the past decade.[1]. Aberrant expression of piRNA is a key character with feasible implications for diagnosis or prognosis in multiple types of cancers.[9]. Qu et al suggested that serum piRNAs expression could be used to be biomarkers for CRC detection and to predict prognosis.[14]. Based on these studies, we deduced that detection of piRNAs in GJ might provide a non-invasive tool for diagnosis and prognosis for GC. PiR-1245 could be served as a novel oncogene and a feasible prognostic biomarker for CRC.[17]. These results suggested that piR1245 could show an important role in CRC tumorigenesis. The relationship between the levels of GJ piR-1245 expression and the survival rate of GC patients was identified to elucidate its possibility for prognostic prediction
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