Abstract

In our clinical trials of gastric freezing for treatment of peptic ulcer, we have found on gastroscopic examination some increase in friability of the gastric mucosa. Microscopic examination of biopsy specimens disclosed no significant abnormalities early or late after freezing. There was an early decrease in motility after freezing, and in some instances an early decrease in the 12-hr, overnight secretion of free hydrochloric acid. However, there was no persistent, significant change apparent after gastric freezing, as evaluated by these anatomic and physiologic studies.

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