Abstract
190 Background: Gastric epithelial dysplasia (GED) can be morphologically categorized into adenomatous and foveolar types. To date, there have been few studies on the clinical characteristics of GEDs according to the morphologic types. Therefore, we here aimed to elucidate the clinicopathologic characteristics of patients with GED and the long-term follow-up results after endoscopic resection according to the morphologic characteristics of GEDs. Methods: A total of 357 patients who underwent endoscopic resection for GEDs at Pusan National University Hospital between January 2008 and December 2009 were included in the study. Results: Patients with GED were divided into 3 groups: adenomatous (n = 167, 46.8%), foveolar (n = 103, 28.9%), and hybrid (n = 87, 24.3%) types. Compared to the adenomatous type, foveolar type lesions were more frequently located in the antrum/pylorus, flat/depressed lesions, and normal/reddish in color; and showed more frequent high-grade dysplasia. During the follow–up period (median, 37.3 months), the overall incidence of synchronous and metachronous lesions was 20.8% and 20.1%, respectively; of these, the incidence of synchronous and metachronous gastric cancer was 8.7% and 5.4%, respectively. There were no significant differences in the incidence of synchronous and metachronous lesions according to morphologic types. Conclusions: GEDs appear to have different clinicopathologic characteristics according to morphologic types. Irrespective of the morphology, synchronous and metachronous gastric cancers are commonly found after endoscopic resection of GEDs. Therefore, close follow-up surveillance after endoscopic resection of GEDs should be performed for all patients.
Highlights
Gastric epithelial dysplasia (GED) can be morphologically categorized into adenomatous and foveolar types
When the locations of the GEDs were divided according to the longitudinal and circular directions, adenomatous type lesions were found to be more frequently located in the body/fundus and in the lesser curvature side than the foveolar and hybrid types
We found that adenomatous GEDs were more likely to occur in the gastric body and lesser curvature side of the stomach, whereas foveolar GEDs were mainly located in the gastric antrum and non-lesser curvature side of the stomach
Summary
Gastric epithelial dysplasia (GED) can be morphologically categorized into adenomatous and foveolar types. There have been few studies on the clinical characteristics of GEDs according to the morphologic types. We here aimed to elucidate the clinicopathologic characteristics of patients with GED and the long-term follow-up results after endoscopic resection according to the morphologic characteristics of GEDs. Gastric epithelial dysplasia (GED) is an unequivocal neoplastic non-invasive proliferation widely accepted as a precursor to gastric adenocarcinomas [1]. The frequency of GED markedly increases with age, especially in patients in their fifth decade of life and above. This tendency may GED, which encompasses gastric adenoma, is a relatively common disease entity in Korea. On the basis of these data, endoscopic resection has been recently recommended as the standard treatment for GEDs after prior histologic confirmation of dysplasia [12,13,14]
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