Abstract
AbstractThe preventive effects of Teucrium stocksianum (lyophilized water extract) on ulcer formation induced by severe, necrotizing agents such as absolute alcohol, 60% ethanol in 150mMHCl(HCl-ethanol), and 0.2NNaOH were studied in rats. T. stocksianum when given orally (p.o.) but not intraperitoneally exhibited a dose-dependent gastric cytoprotective effect to the three necrotizing agents tested. The I mucosal protective action of T. stocksianum was attenuated by pretreatment with indomethacin (5 mg/kg, subcutaneously). T. stocksianum (500 mg/kg twice per day, p.o.) had no significant effect on the healing process of ethanol-induced gastric ulcers 24, 48 and 72 h after ulcer induction. T. stocksianum (500 mg/kg, p. o.) did not afford. protection against cysteamine-induced duodenal ulcera- i Hon. In vitro studies showed that T. stocksianum dose-dependently inhibited ethanol-induced contractions, of rat fundic strip muscles. This effect was abolished by the cyclooxygenase inhibitor, indomethacin. In addit...
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