Gastric Clearance Does Not Influence Glycemic Response to Cranberry Juice in Metabolic Syndrome Subjects.

Abstract

Acetaminophen (AC) may be used to estimate gastric clearance effects on glycemic response to a dietary challenge. Healthy (n=6) and metabolic syndrome (MSD) subjects (n=14; BMI >30) consumed reduced calorie cranberry juice (RCCBJ) (74 Cal/240 ml) or standard cranberry juice (CBJ) (110 Cal/240 ml) in single crossover fashion with 1 g AC. AC plasma concentration was measured pre‐challenge (0‐min) and 30, 60 and 120 min post‐prandially with HPLC. Plasma AC in healthy subjects after RCCBJ at 0, 30, 60 and 120 min was 0.14±0.20, 3.52±3.14, 16.07±8.54, 18.37±6.11 μg/ml. Plasma AC in healthy subjects after CBJ at 0, 30, 60 and 120 min was 0.33±0.37, 3.54±4.79, 19.80±15.03, 15.53±5.40 μg/ml. Plasma AC in MSD subjects after RCCBJ at 0, 30, 60 and 120 min was 0.11±0.25, 4.36±4.75, 10.64±6.60, 10.75±6.70 μg/ml. Plasma AC in MSD subjects after CBJ at 0, 30, 60 and 120 min was 0.16±0.28, 5.08±7.15, 12.86±10.15, 10.94±6.92 μg/ml. AC area under the curve (μg/ml·min) for healthy and MSD subjects to RCCBJ were 1382±523 and 934±569 respectively. AC area under the curve (μg/ml·min) for healthy and MSD subjects to CBJ were 1468±891 and 1062±644 respectively. No statistically significant differences in clearance were observed between RCCBJ and CBJ in either population, therefore in studies of cranberry juice glycemic response, gastric clearance is probably not a factor.