Gastric cancer stem cell: Carcinogenesis and targeted personalized therapies of cancer stem cell

Abstract

Gastric cancer (GC) is one of the most common cancers in worldwide range which ranks fifth, and it is also third most common cancerous death reason. Although there has been a decline in the rate of incidence and mortality over recent fifty years, cure for GC is extremely hard to achieve. The symptoms are not conspicuous at early stage of the GC patients usually, which is the reason GC is diagnosed at terminal stage. And it is worse that the prognosis effect is outrageously bad, the median survival times are mostly less than a year. Under this condition, prevention is the most efficient method to reduce the incidence and mortality, meanwhile, the application of newly emerged therapy should be attached importance to GC. To create accurate treatment to achieve this goal, it is necessary to comprehend the mechanism of the carcinogenesis, and mechanism of cancer development, the critical transformation points derived from those mechanism will divide the different methodology applying period. This article mainly focuses on the cancer stem cell (CSC) aspect of carcinogenesis, cancer development to inform the points which can be utilized to intervene and new therapy method.