Abstract
.Significance: Hyperspectral imaging (HSI) is an emerging optical technique that has a double function of spectroscopy and imaging.Aim: Near-infrared hyperspectral imaging (NIR-HSI) (900 to 1700 nm) with the help of chemometrics was investigated for gastric cancer diagnosis.Approach: Mean spectra and standard deviation of normal and cancerous pixels were extracted. Principal component analysis (PCA) was used to compress the dimension of hypercube data and select the optimal wavelengths. Moreover, spectral angle mapper (SAM) was utilized as chemometrics to discriminate gastric cancer from normal.Results: Major spectral difference of cancerous and normal gastric tissue was observed around 975, 1215, and 1450 nm by comparison. A total of six wavelengths (i.e., 975, 1075, 1215, 1275, 1390, and 1450 nm) were then selected as optimal wavelengths by PCA. The accuracy using SAM is up to 90% according to hematoxylin–eosin results.Conclusions: These results suggest that NIR-HSI has the potential as a cutting-edge optical diagnostic technique for gastric cancer diagnosis with suitable chemometrics.
Highlights
Gastric cancer is one of the most serious illnesses in the world because of its high morbidity and mortality.[1]
These results suggest that NIR-Hyperspectral imaging (HSI) has the potential as a cutting-edge optical diagnostic technique for gastric cancer diagnosis with suitable chemometrics
The tissue-level accuracy and patient-level accuracy were 88% and 93%, respectively.[9]. These results demonstrated the feasibility of HSI with chemometrics to discriminate gastric cancer from normal tissue with relatively high sensitivity, specificity, and accuracy
Summary
Gastric cancer is one of the most serious illnesses in the world because of its high morbidity and mortality.[1] Currently, early detection and localization of gastric cancer sites are critical to decrease the mortality. It is a big challenge for clinicians who routinely utilize conventional white-light reflectance endoscope to accurately identify and localize early dysplasia, carcinoma in situ, and flat mucosal cancers in the stomach.[2] The serum markers fail to diagnose or screen gastric cancer with sufficient sensitivity and specificity despite being helpful for monitoring response to therapy and detecting cancer recurrence. As an emerging spectroscopy and imaging modality for Journal of Biomedical Optics
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
