Abstract
To explore the role of blood glucose regulation in gastric bypass surgery is a hot point in the treatment of diabetes in recent years. Current evidence is very clear that the gastric bypass surgery is one of the most promising therapy to cure type 2 diabetes. However, the mechanisms are not yet understood. Studying the mechanism of surgical treatment can not only understand the pathogenesis of diabetes, but also have important scientific and practical significance for clinically and safely carrying out this therapy. As is known to all, the body's energy metabolism and glucose homeostasis are regulated by the hypothalamus. Thus, we summarize the process mechanism of central regulation of glucose homeostasis in post-surgery and find that the hypothalamus after gastric bypass surgery showed enhanced expression of peripheral signal receptors, enhancement of leptin signal and insulin signal, and expression changes of certain related genes, then issued neuroendocrine signals to control peripheral insulin sensitivity and glucose metabolism. Then, we prove that the improvement of peripheral metabolic status is caused by the decisive role of central regulation in post-surgery. These funding provide scientific basis to improve the understanding of the neuroendocrine mechanism of diabetes and the development of clinical implication of gastric bypass surgery.
Highlights
The role of blood glucose regulation in gastric bypass surgery is unquestionable
Most of the researches on the treatment mechanism have searched for answers in the periphery, and there is a lot of evidence for improving peripheral metabolism
A hormone involved in food intake and energy metabolism control of the body and the signal regulation of glucose and insulin, its receptors are expressed in the brain, and there are almost no targets in the periphery
Summary
The role of blood glucose regulation in gastric bypass surgery is unquestionable. A 12-year observational prospective follow-up study of Roux-en-Y gastric bypass surgery in the United States show that Surgery can effectively alleviate and prevent type 2 diabetes in the long term [3]. Most of the researches on the treatment mechanism have searched for answers in the periphery, and there is a lot of evidence for improving peripheral metabolism. They are not able to clarify the mechanism of these changes. Huangna Quan and Xue-jun Yang: Gastric Bypass Surgery Regulates Glucose Homeostasis Through the Hypothalamus
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