Abstract
Alterations in gastric mucosal hemodynamics during the development of restraint-induced gastric erosions in the rat were studied using the indicator fractionation technic with86Rb. Cardiac output, gastric flow fractions and gastric blood flow were determined in rats subjected to zero (control), 1/2, 4 and 24 hours of restraint. No correlation was found between gastric mucosal blood flow changes and the natural development of restraint erosions. The possible role of local microcirculatory adjustments, independent of total mucosal flow, in the genesis of restraint lesions is discussed.
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