Abstract
(-)-Cathinone, chemically known as (-)-a-aminopropiophenone is an active constituent of khat (Catha edulis Forsk.). The leaves of khat plant are chewed customarily in Southern Arabia and Eastern Africa, to attain a state of euphoria and stimulation. WHO classified khat as drug of abuse. U.N. Narcotic Laboratory considered cathinone as natural amphetamine, due to its close similarity with that of amphetamine. The controversial observations on the gastrointestinal effects of khat chewing prompted us to study the effect of cathinone on experimentally induced gastric ulcers in rats, and compare it with that of amphetamine
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