Abstract
It has been recognized for some time that hyperthyroidism causes changes in gastric acidity and that in some cases there is an absence of hydrochloric acid. Hardt 1 in 1916 called attention to the fact that thyroid feeding caused lowered gastric acidity in normal dogs. Barker 2 in 1918 mentioned hypochlorhydria, and King 3 in 1919 noted that achlorhydria and achylia occur in hyperthyroidism. Lockwood 4 in 1925 and Moll and Scott 5 in 1927 reported a high incidence of achlorhydria in exophthalmic goiter. Following this line of thought, Truesdell 6 in 1926 showed that a lowering of acidity could be produced regularly by feeding thyroid to dogs, and in some achlorhydria was produced. On the other hand, Crile 7 and his co-workers have held that the same mechanism that produced hyperthyroidism could in some cases produce peptic ulcer. He has also stated that denervation of the suprarenals and a
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