Abstract
Acid secretion by the parietal cell of the gastric mucosa depends on activation of the acid pump, the gastric H,K-ATPase. This enzyme is expressed in high quantities by the parietal cell. The site of acid secretion in the parietal cell is the secretory canaliculus. This specialized structure is considered to be an infolding of the apical plasma membrane. The active H,K-ATPase is present in the microvilli lining the secretory canaliculus. When inactive the pump is found in cytoplasmic tubules.
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