Gastric acid secretion in response to liver extract and to mixtures simulating its content of total and free amino acids

Abstract

GASTRIC ACID SECRETION IN RESPONSE TO LIVER EXTRACT AND TO MIXTURES SIMULATING ITS CONTENT OF TOTAL AND FREE AMINO ACIDS. E. J. Feldman, R. Melendez, and M. I. Grossman, VA Wadsworth Hospital Center, Los An 1 C lff i Liver extract (LE) is a commonly !~e?&.f&la$no~* gastric acid secretion. The purpose of this study was to determine whether the acid secretory response to LE could be mimicked by giving a mixture of amino acids simulating those found in LE. Amino acid analysis of LE showed that about 50% by weight is amino acids (AA) and that one-half of this amount is in the form of free amino acids (FAA). In four dogs with gastric fistulas, using the intragastric titration method, dose response studies were carried out with LE and with mixtures of amino acids that matched the total (AA) or the free (FAA) amino acid composition of LE. All solutions were adjusted to pH 7.0 and osmolality to 290 mOsm kg-l. At all doses of LE studied (.16X, .32%, .63X. 1.3% and 2.5%), the total AA mixture and the FAA mixture stimulated secretion to the same degree as LE. LE cont., %(gm dl-1) .16% .32X .63% 1.3% 2.5% Ht secretion, am101 h-l