Abstract
A number of published reports have implied a greater than normal incidence of peptic ulcer in patients with chronic obstructive pulmonary emphysema. Thus, in several clinical and/or autopsy stUdies, approximately 15 to 28 per cent of emphysema patients had suffered at some time from an acute or chronic peptic ulcer.!-5 Weber and Gregg6 analyzed the relationship of thes3 two diseases from another point of view: they found that of 70 patients with gastric ulcer, 30 (43 per cent) had pulmonary emphysema. The actual incidence of peptic ulcer in the general obstructive emphysema population cannot be ascertained from these reports. In most instances the emphysema patients were hospitalized or came under medical observation because of severe pulmonary disease. It would seem, therefore, that the patients in the various series cited were specially, although not deliberately, selected. Nevertheless, peptic ulcer seemed to be associated more commonly with obstructive emphysema than with many other chronic diseases.! Mechanisms responsible for the increased incidence of peptic ulcers were considered, but no author presented experimental evidence to account for the association of
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