Abstract
A procedure for the separation, characterization and detection of picogram quantities of biogenic indolealkylamines contained in cerebrospinal fluid (CSF) has been described. It involves extracting these amines from CSF, converting them to their respective O- and/or N-perfluoroacyl derivatives with N-heptafluorobutyrylimidazole, and finally subjecting the mixture of derivatives to gas-liquid chromatographic separation. The unknown amines may be identified by direct comparison with known standards. Quantification can be achieved through comparison of the indolealkylamine peak areas with standard curves prepared from pure derivatized standards.
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