Gasless trans-axillary endoscopic versus conventional open hemithyroidectomy for thyroid cancer patients: A propensity score-matched analysis of quality of life and oncological outcomes: A cross-sectional questionnaire study

Abstract

BackgroundThyroid cancer predominantly affects young females who seek surgical intervention not only for excellent oncological outcomes but also for a high quality of life (QOL) and favorable cosmetic and functional outcomes. The gasless trans-axillary endoscopic (GTAE) approach is a commonly used remote access technique for thyroid surgeries. It holds the potential for comparable oncological outcomes and superior QOL, cosmetic, and functional outcomes. However, robust evidence supporting this hypothesis is scarce. Materials and MethodsWe collected data from patients diagnosed with papillary thyroid carcinoma who underwent hemithyroidectomy with central compartment dissection at Peking Union Medical College Hospital (PUMCH) between December 2019 and January 2023. After applying propensity-score matching analysis (PSMA), a total of 424 cases were included. For oncological outcomes, patients in both groups were prospectively followed through regular outpatient visits. The QOL, functional, and cosmetic outcomes were assessed using a cross-sectional online questionnaire, including EORTC-THY34 for QOL, PSAQ for cosmetic outcomes, SIS-6 for swallowing functions, and VHI-10 for voicing functions. We further compared oncological outcomes, QOL, functional, and cosmetic outcomes between these two groups. ResultsA total of 274 cases provided validated responses: 141 underwent the GTAE approach, and 134 underwent the conventional open (CO) approach. The operation time was approximately 60 minutes longer in the GTAE group. Notably, there was no difference in complications between the two approaches. Rates of suspicious recurrence in both groups remained low and showed no significant differences (2.55% vs. 1.57%, p>0.05). No pathological confirmed recurrence was reported in either group. Patients with the GTAE approach showed better body image and less joint pain (EORTC-THY34), better swallowing (SIS-6), and better cosmetic outcomes (PSAQ). Voice outcomes showed no difference between these two approaches (VHI-10). ConclusionCompared to the CO approach, hemithyroidectomy with central compartment dissection via the GTAE approach in low-risk patients maintains comparable oncological outcomes while offering better QOL, cosmetic benefits, and functional outcomes.