Abstract

Proton magnetic resonance imaging (1H MRI) of gases can potentially enable functional lung imaging to probe gas ventilation and other functions. Here, 1H MR images of hyperpolarized (HP) and thermally polarized propane gas were obtained using ultrashort echo time (UTE) pulse sequence. A 2-dimensional (2D) image of thermally polarized propane gas with ∼0.9 × 0.9 mm2 spatial resolution was obtained in <2 seconds, showing that even non-HP hydrocarbon gases can be successfully used for conventional proton magnetic resonance imaging. The experiments were also performed with HP propane gas, and high-resolution multislice FLASH 2D images in ∼510 seconds and non-slice-selective 2D UTE MRI images were acquired in ∼2 seconds. The UTE approach adopted in this study can be potentially used for medical lung imaging. Furthermore, the possibility of combining UTE with selective suppression of 1H signals from 1 of the 2 gases in a mixture is shown in this MRI study. The latter can be useful for visualizing industrially important processes where several gases may be present, eg, gas–solid catalytic reactions.

Highlights

  • Magnetic resonance imaging (MRI) is an established tomographic modality for morphological and functional medical imaging to detect abnormalities in the structure and function of human tissues and organs

  • FLASH MRI HP propane was produced via heterogeneous hydrogenation of propene with pH2 over Rh/TiO2 catalyst [31]

  • Note that significant signal enhancement obtained via Parahydrogen-induced polarization (PHIP) is crucial for 1H FLASH MRI of the gaseous phase

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Summary

Introduction

Magnetic resonance imaging (MRI) is an established tomographic modality for morphological and functional medical imaging to detect abnormalities in the structure and function of human tissues and organs. The presence of numerous air–tissue interfaces in the lungs leads to significant susceptibility-induced magnetic field gradients, resulting in very short T2* times of the human lung protons [ϳ1 millisecond in a 1.5 T nuclear magnetic resonance (NMR) scanner [3]]. This further degrades the SNR in the MR images of the lungs.

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