Abstract
Comparison of the gas chromatograms of crude urine extracts indicated major quantitative and qualitative differences in the 17-ketosteroid patterns of a normal and virilized woman before and after oophorectomy. The differences persisted in the same areas of the chromatogram following chemical purification. Metabolites of testosterone, notably androstane-17β-ol-3-one and 3α, 17β and 3β, 17β-androstanediols appeared to account for the massive virilization in the presence of a low total 17-ketosteroid. The correlation of gas and paper analysis was good. The use of gas chromatography as a monitoring tool for completion of chemical reactions and operations is inferred. The data presented suggest that screening of crude extracts can reveal valuable information regarding steroid biosynthesis which may be useful for clinical and research purposes.
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