Abstract
Benzethonium chloride (I), used as a detergent, disinfectant and pharmaceutical preparation, was determined by gas-liquid chromatography of the reduction product obtained by treatment with sodium borohydride and nickel(II) chloride. The reduction product of I was identified as 2-2-[ p-(1,1,3,3-tetramethylbutyl)-phenoxy]ethoxy ethyldimethylamine by mass spectrometry, nuclear magnetic resonance spectroscopy and elemental analysis. In the reduction, the benzyl group of I was eliminated as toluene. The procedure is suitable for the assay of 10–100 μg/ml of aqueous preparations of I, and useful for the routine analysis of I, as the reduction takes place quantitatively, the reagents are relatively safe to handle and there is no need for complicated apparatus such as in catalytic hydrogenation.
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