Abstract
Most earlier studies of estrogenic steroids in urine with a clinical bias have been based upon colorimetric evaluation after purification of the urinary steroid fraction. Frequently, in systematic studies, samples have not been standardized with respect to time of collection or to inherent diurnal variation. In the present investigation, in order to provide an inherently higher level of sensitivity and resolution, gas-liquid chromatography of silylated estrogens derived from urine has been adopted as the analytic method. Analysis was made upon 24-hr samples taken under standardized conditions. In post-menopausal women, the ratio of estriol to estrone + estradiol (17β-estradiol) did not differ in subjects with mammary tumors when compared with normal subjects. In premenopausal women, however, breast cancer patients had a markedly lower ratio of estriol to estrone + estradiol than did normal subjects. The data reported substantiate the potential utility of the procedure as a cancer detection test applicable to high-risk groups of premenopausal women.
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