Abstract
Background: Annonaceae and Apocynaceae families are known for their plethora of pharmacotherapeutic potential. Objectives: To evaluate antipsoriatic potential (ultraviolet [UV]-induced photodermatitis and tail model) and gas chromatography-mass spectrometry (GC-MS) studies on developed formulations from the plant extracts. Materials and Methods: Formulations of ethanolic extracts of Carissa congesta and Catharanthus roseus and petroleum ether extracts of Annona squamosa and Polyalthia longifolia were evaluated for antipsoriatic activity (UV-induced photodermatitis and tail model) at 250 and 500 mg/kg. GC-MS studies were done subsequently after 6 months. Formulation batches were tested by different tests, viz., pH, viscosity, spreadability, washability, homogeneity, grittiness, drug content, Sudan red, bleeding, and sensitivity tests. Results: Histopathology studies indicated the absence of Munro's microabscess, regular elongation of rete ridges, capillary loop dilatation, granular cell layer, and prominent parakeratosis at 500 mg/kg. Formulations of the plant extracts did not reveal toxic components by GC-MS interpretation. No greasiness was observed during washing. Uniform homogeneity was observed with neither clumps nor large aggregates. The dispersed globules appeared red against colorless water background. Bleeding time was found to be stable during the experimentation.Conclusion: Developed topical plant formulations showed antipsoriatic potential on selected models. The GC-MS studies confirmed the presence of no drastic changes in the quantity of active constituents assuring its stability.
Highlights
Annonaceae and Apocynaceae families are known for their plethora of pharmacotherapeutic potential
The leaves of Carissa congesta (CC) and Catharanthus roseus (CR) were air‐dried in the absence of sunlight, powdered with a mechanical grinder, and passed through sieve no. 40
From CC, components obtained were oleic acid, squalene, etc., CR showed the presence of n‐hexadecanoic acid, ethyl ester, Vitamin E, 9,12,15‐octadecatrienoic acid, 2‐[(trimethylsilyl) oxy]‐1‐[{(trimethylsilyl) oxy} methyl] ethyl ester, phytol, 3‐epivindolinine, and oleic acid.[11]
Summary
Annonaceae and Apocynaceae families are known for their plethora of pharmacotherapeutic potential. Objectives: To evaluate antipsoriatic potential (ultraviolet [UV]‐induced photodermatitis and tail model) and gas chromatography‐mass spectrometry (GC‐MS) studies on developed formulations from the plant extracts. Materials and Methods: Formulations of ethanolic extracts of Carissa congesta and Catharanthus roseus and petroleum ether extracts of Annona squamosa and Polyalthia longifolia were evaluated for antipsoriatic activity (UV‐induced photodermatitis and tail model) at 250 and 500 mg/ kg. Formulation batches were tested by different tests, viz., pH, viscosity, spreadability, washability, homogeneity, grittiness, drug content, Sudan red, bleeding, and sensitivity tests. Formulations of the plant extracts did not reveal toxic components by GC‐MS interpretation. Uniform homogeneity was observed with neither clumps nor large aggregates. Conclusion: Developed topical plant formulations showed antipsoriatic potential on selected models.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
