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Abstract
BackgroundPreterm birth and feeding are the most important pathogenic factors of neonatal necrotizing enterocolitis (NEC). Metabonomic has been widely used in the diagnosis and treatment of other diseases, but there is no research on the related diseases of premature infants. Compared with full-term infants, the metabolism of preterm infants has its own specificity, so it can easily lead to NEC and other digestive tract inflammatory diseases. Metabonomic may be applied to the diagnosis of preterm related diseases, such as NEC.MethodsThe model was established with premature infant serum samples from 19 premature infants in our hospital, which was compared with the full-term infant control group. Serum was analyzed by gas chromatography-mass spectrometry (GC-MS), coupled with the analysis of serum metabolic characteristics. The variable important in projection, P value and Pearson correlation coefficient of samples were analyzed by using SIMCA, SPSS and other multivariate statistical analysis software.ResultsCompared to the term infants, premature infants had significantly higher levels of luteolin, and lower levels of xylose, O-succinyl-L-homoserine and lauric acid in the serum. There were some correlations among several different metabolites and clinically related indices (albumin, total bilirubin) for premature birth related diseases.ConclusionsThere are metabolic alterations in the serum of premature infants, which make contribution to the diagnosis of NEC.
Highlights
Preterm birth and feeding are the most important pathogenic factors of neonatal necrotizing enterocolitis (NEC)
The physicians diagnosing NEC were blinded to the results of the gas chromatography-mass spectrometry (GC-MS) detection of serum
The Orthogonal partial least squares analysis (OPLS-DA) model shows that the metabolic profile of preterm infants before feeding is distinctly separated from the term infants group
Summary
Preterm birth and feeding are the most important pathogenic factors of neonatal necrotizing enterocolitis (NEC). Metabonomic has been widely used in the diagnosis and treatment of other diseases, but there is no research on the related diseases of premature infants. Compared with full-term infants, the metabolism of preterm infants has its own specificity, so it can lead to NEC and other digestive tract inflammatory diseases. Metabonomic may be applied to the diagnosis of preterm related diseases, such as NEC. With the improvement of the level of economy and the accuracy of clinical diagnosis and treatment, the survival of premature infants is increasing [1]. Due to the immature development of organs and systems in preterm infants, metabolism is more susceptible to the internal and external environment, which leads to the occurrence of various systemic diseases [2]. The study uses universal screening to select the metabolites closely related to NEC, because the results have not been validated
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