Abstract
Six chiral polysiloxanes were prepared by block condensation of 3-(dichloromethylsilyl)-2-methylpropionic acid 2′,2′,2′-trifluoroethyl ester with disodium tetramethyldisiloxane1-,3-diolate and subsequent nucleophilic displacement with chiral amines. The polysiloxanes were coated on to capillaries and the capillary columns were used for the gas chromatographic separation of pharmaceutical enantiomers. The columns showed sufficient enantio-selectivity and thermal stability to separate various pharmaceuticals into enantiomeric pairs within a reasonable time. ( S)-Valine-( R)-1-( α-naphthylethyl)amide-modified polysiloxane showed better enantioselectivity, and ( S)-valine-( d)-menthylamide-modified polysiloxane gave a higher coating efficiency than the other phases.
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