Abstract
Carnitine [4-(N-trimethylamino)-3-hydroxybutyrate, (I)] is determined inhigh concentrations in skeletal musculature, heart, and epididymis, and in lower concentrations in the liver, brain kidneys, and blood [4, 7]. At the present time, it is known that (I) is an active carrier in the transport of fatty acids across the internal mitochondrial membranes to the sites of 8-oxidation [7]; (I) is also a most important factor in the conversion of acetyl CoA in the cells of the sex glands [5], and is a regulator of the catabolism of branched aminoacids in the skeletal musculature [3, i0]. Methods for the quantitative determination of (I) in the free and esterified form have been described [6], whereby the most sensitive and specific is the determination of the enzyme activity of carnitine acetyl transferase [8, 12] which requires work with the radioactive :~C-acetyl CoA. The gas chromatographic analysis of (I) is applied significantly less often [ii].
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