Abstract
The article presents a novel gas-chemical approach for 225Ac/213Bi generators, which provides effective separation of 213Bi from parent 225Ac. The main problem with the generators of high activity is the radiation stability of sorbents, which is not substantial in this gas-chemical method of separation, where only radiationally stable inorganic materials are used. The approach includes heating at high temperature (about 900–1000 °C) 225Ac sample deposited on a backing material (Nb, quartz glass, stainless steel) in hydrogen-containing inert gas flow. Actinium is non-volatile in these conditions, while Bi sublimes and is deposited on a catcher-foil along a temperature gradient. Niobium was found to be the best of the used material for both the starting backing and catcher-foil. The effective activation energy of carrier-free amount of Bi-sublimation from Nb-backing as 102 ± 9 kJ/mol has been calculated, and standard enthalpy of desorption of Bi on Nb from thermochromatographic data has been evaluated as 269 ± 13 kJ/mol 213Bi may be recovered for the consequent preparation of radiopharmaceuticals by washing from the catcher-foil surface. The gas-chemical method has been demonstrated to be a promising approach for 225Ac/213Bi generators for its application in targeted alpha therapy.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
