Gas-Antisolvent (GAS) Crystallization of Aspirin Using Supercritical Carbon Dioxide: Experimental Study and Characterization

Abstract

Aspirin, which is used as a pain killer and is recommended to cure diseases such as arthritis, was precipitated using the gas-antisolvent (GAS) process. The objective of this study was to investigate the effects of four operating parameters—namely, antisolvent addition, process temperature, solute concentration, and solvent type (methanol and acetone)—on the final product particle size distribution, morphology, and crystallinity. In accordance to particle size analysis and scanning electron microscopy (SEM), it was observed that the increment of antisolvent addition rate reduced the mean size of precipitated particles and the size distributions became narrower. Furthermore, the process temperature and the solute concentration had a reverse effect on the precipitated aspirin particle size. The crystallized particles had a mean size between 48 μm and 124 μm. In contrast, particles precipitated from methanol solution had smaller mean size than from acetone. X-ray diffraction (XRD) and differential scanning c...