Abstract
Epidemiological observations have shown an inverse association between consumption of Allium vegetables (e.g., onions and garlic) and pancreatic cancer risk. The cancer preventive effect of Allium vegetables has been attributed to organosulfur compounds. The objective of this study was to determine the efficacy of diallyl trisulfide (DATS), a garlic‐derived organosulfur compound, against pancreatic cancer cells. Treatment with DATS inhibited the growth of MIAPaca2 and PL45 pancreatic cancer cells in a dose‐dependent manner. DATS induced apoptosis in pancreatic cancer cells as determined by cytoplasmic‐associated DNA fragmentation assay after exposure to DMSO (control) or DATS (20, 40, and 60 μmol/L) for 24 h. Exposure of pancreatic cancer cells to DATS increased levels of cleaved caspase 3 and induced proteolytic cleavage of poly‐(ADP‐ribose) polymerase (PARP). In addition, DATS treatment upregulated the expression of pro‐apoptotic Bim‐s and Bim‐L isoforms in MIAPaca 2 and PL45 cells. In conclusion, this study shows that DATS induces apoptotic cell death in pancreatic cancer cells and supports further investigation of DATS as a chemopreventive agent for pancreatic cancer.
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